Cortical Underpinnings of Electrocorticography
Electrodes placed on the surface of the brain are commonly used to map cortical activity. Microfabricated versions of electrocorticography (ECoG) arrays have the potential to provide greater coverage and resolution, but how do the signals they record relate to the firing of neurons within the cortex? I used two methods to answer this question:
1. Localized modulation of pyramidal neurons with optogenetics in transgenic mice.
2. Simultaneous ECoG and intracortical electrophysiological recordings.
The brain consumes a vast amount of energy for its size and dynamically redistributes its blood supply to areas that need it most. This is the basis of fMRI and other hemodynamic methods of measuring brain activity. I researched neurovascular and neurometabolic coupling using two newly developed microscopes in collaboration with Ramin Pashaie's lab:
1. Optogenetic investigation of neurovascular coupling with a spatial light modulator microscope
2. Optogenetics + Optical Coherence Tomography